NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

carbon C 11 martinostat
A radioconjugate composed of martinostat, a histone deacetylase (HDAC) inhibitor, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET)/magnetic resonance imaging (MRI). Upon intravenous administration of carbon C 11 martinostat, the martinostat moiety targets and binds to HDAC on tumor cells. Upon PET/MRI imaging, this radioligand may allow for the assessment of HDAC-expressing tumor cells. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Check for active clinical trials using this agent. (NCI Thesaurus)

martinostat C-11