NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- CD3+/CD19+ cell-depleted unrelated or partially matched donor-derived allogeneic peripheral blood stem cells
A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of CD3-positive (CD3+) T cells and CD19-positive (CD19+) B cells via leukapheresis with potential immune reconstituting activity. The CD3+/CD19+ cell-depleted PBSCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD) and Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: CD3+ and CD19+ cell-depleted allogeneic PBSCs derived from an unrelated or partially matched donor
CD3+ T-cell-depleted/CD19+ B-cell-depleted unrelated or partially matched donor-derived allogeneic peripheral blood stem cells
CD3+/CD19+ cell-depleted unrelated or partially matched donor-derived allogeneic PBSCs