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8-chloroadenosine

An antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-ATP), which functions as a ribonucleoside analogue and competes with ATP during transcription. Therefore, this agent causes RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis.

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Synonym:	8-chloro-adenosine 8-Cl-adenosine
Abbreviation:	8-Cl-Ado
Chemical structure:	adenosine, 8-chloro-

8-chloroadenosine

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