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interleukin-15/interleukin-15 receptor alpha complex-Fc fusion protein XmAb24306

An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 stimulates the proliferation of natural killer (NK) cells and memory CD8+ T cells. The memory T cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. XmAb24306 does not require endogenous IL-15Ra for its activation.
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Synonym:IL15/IL15Ra complex-Fc fusion protein XmAb24306
IL15/IL15Ra-Fc fusion protein XmAb24306
Code name:RO 7310729
RO-7310729
RO7310729
XmAb 24306
XmAb-24306
XmAb24306
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