bioadhesive nanoparticles-encapsulating avobenzone/octocrylene plus diosmin/ferulic acid/cytisine/trans-resveratrol sunscreen

A sunscreen formulation containing bioadhesive nanoparticles (BNP) encapsulating the broad-spectrum ultraviolet radiation (UVR) protectors avobenzone and octocrylene plus additional naturally-occurring active ingredients, including the flavonoid diosmin, the phenolic phytochemical ferulic acid, the alkaloid cytisine and the polyphenol trans-resveratrol, with potential free radical scavenging, anti-oxidant and skin protective activities. Upon topical application of the BNP-encapsulating avobenzone/octocrylene plus diosmin/ferulic acid/cytisine/trans-resveratrol sunscreen, avobenzone and octocrylene absorb UVR and prevent exposure of the skin to UVR, thereby preventing the formation of UVR-induced reactive oxygen species (ROS). This prevents oxidative damage to DNA, double-stranded DNA breaks and cellular skin damage. The other active ingredients may protect the skin through their ability to scavenge ROS. BNP prevents penetration of the UVR protectors into the skin.