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abiraterone amorphous solid dispersion formulation DST-2970

An orally bioavailable, amorphous solid dispersion formulation of the steroidal compound abiraterone, with potential antiandrogen activity. Upon oral administration, abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. This may suppress testosterone production by both the testes and the adrenals to castrate-range levels.

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Synonym:	abiraterone KinetiSol formulation DST-2970
Code name:	DST 2970 DST-2970 DST2970

abiraterone amorphous solid dispersion formulation DST-2970

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