acitretin
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis.
| Synonym: | Trimethylmethoxyphenyl-retinoic acid |
|---|---|
| US brand name: | Etretin Soriatane |
| Foreign brand name: | Neotigason |
| Code name: | Ro 10-1670 Ro-10-1670 |
| Chemical structure: | (All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid |