actinium Ac 225 lintuzumab
A radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with potential antineoplastic activity. The monoclonal antibody moiety of actinium Ac 225 lintuzumab specifically binds to the cell surface antigen CD33 antigen, delivering a cytotoxic dose of alpha radiation to cells expressing CD33. CD33 is a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on myeloid leukemia cells.
| Synonym: | 225Ac-HuM195 actinium (225Ac) lintuzumab satetraxetan actinium-225-labeled humanized anti-CD33 monoclonal antibody HuM195 |
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| US brand name: | Actimab-A |
| Code name: | SGN-33 AC-225 |