Ad5-encoding IFNg SP-002
A replication deficient adenovirus type 5 (Ad5) vector encoding for the cytokine human interferon gamma (IFNg; IFN-gamma), with potential antineoplastic and immunomodulating activities. Upon intratumoral administration, Ad5-encoding IFNg SP-002 expresses human IFNg, which binds to and activates the cell-surface IFN-gamma receptor and may stimulate an antiproliferative natural killer (NK) cell response against tumor cells and induce tumor cell apoptosis.
| Synonym: | adenoviral vector Ad5-hIFNg SP-002 adenovirus-5 vector-encoding human interferon gamma SP-002 |
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| Code name: | SP 002 SP-002 SP002 |