Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

adapalene

A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
US brand name:Differin
Code name:CD271
Chemical structure:6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid
6-(4-methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search