allogeneic anti-CD19 CAR-gamma/delta T cells QH103
A preparation of a subset of allogeneic T lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD19 CAR-gamma/delta T cells QH103 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. Gamma/delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. CD19 is overexpressed on certain tumor cell types.
Synonym: | allogeneic anti-CD19 CAR gamma delta T cells QH103 allogeneic anti-CD19 CAR gamma delta-T cells QH103 allogeneic anti-CD19 CAR-gamma-delta T cells QH103 allogeneic CD19 CAR-gamma delta T cells QH103 allogeneic CD19 CAR-gdT cells QH103 |
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Code name: | QH 103 QH-103 QH103 |