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allogeneic anti-CD7 CAR-T cells BEAM-201

A preparation of off-the-shelf (OTS) donor-derived T lymphocytes that have been multiplex base-edited and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD7 CAR-T cells BEAM-201 specifically target and kill CD7-expressing tumor cells. CD7 is a transmembrane glycoprotein expressed by T cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas.
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Synonym:allogeneic anti-CD7 CAR T cells BEAM-201
allogeneic anti-CD7 CAR T cells BEAM-201
Code name:BEAM 201
BEAM-201
BEAM201
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