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allogeneic anti-HA-1 TCR-engineered T cells TSC-100

A preparation of donor-derived T lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility antigen HA-1 (HA1), with potential immunomodulating and antineoplastic activities. Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01 positive patients, allogeneic anti-HA-1 TCR-engineered T cells TSC-100 specifically recognize and bind to HA-1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing HA-1. HA-1 is a lineage-specific antigen found on leukemia cells.
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Synonym:allogeneic T-cell receptor-engineered T cells TSC-100
HA-1-targeting TCR-T cells TSC-100
T-cell receptor engineered donor T cells TSC-100
Code name:TSC 100
TSC-100
TSC100
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