allogeneic CRISPR-Cas9 engineered anti-CD19 CAR T cells CTX110
A preparation of human allogeneic T lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD19 CAR T-cells CTX110 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Removal of endogenous TCR reduces the risk of graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.
Synonym: | allogeneic anti-CD19 CAR CRISPR-edited T cells CTX110 allogeneic anti-CD19 CAR-T cells CTX110 allogeneic CRISPR-Cas9 gene-edited CD19-directed CAR T cells CTX110 allogeneic CRISPR-Cas9-engineered anti-CD19 CAR T cells CTX110 |
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Code name: | CTX 110 CTX-110 CTX101 CTX110 |