allogeneic HPV-specific CD4+ T lymphocytes

A preparation of allogeneic T lymphocytes, collected from a haploidentical donor of the patient after vaccination with human papillomavirus (HPV) vaccine series, and depleted of CD8+ lymphocytes, with potential antiviral and antineoplastic activities. Upon administration, allogeneic HPV-specific CD4+ T lymphocytes may induce selective toxicity in HPV-positive cancer cells and other HPV-infected cells. HPV is associated with various cancer cell types. The depletion of CD8+ lymphocytes from the donor cell preparation may lower the risk of graft-versus-host disease (GvHD).