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alvocidib hydrochloride

The hydrochloride salt form of alvocidib, a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.
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Synonym:flavopiridol
flavopiridol hydrochloride
Abbreviation:FLAVO
Code name:HL-275
HMR 1275
HMR-1275
HMR1275
L 868275
L-86-8275
L-868275
L868275
MDL 107,826A
MDL-107826A
Chemical structure:(-)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
IND number:46211
NSC code:649890
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