alvocidib hydrochloride
The hydrochloride salt form of alvocidib, a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.
| Synonym: | flavopiridol flavopiridol hydrochloride |
|---|---|
| Abbreviation: | FLAVO |
| Code name: | HL-275 HMR 1275 HMR-1275 HMR1275 L 868275 L-86-8275 L-868275 L868275 MDL 107,826A MDL-107826A |
| Chemical structure: | (-)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride |
| IND number: | 46211 |
| NSC code: | 649890 |