amcenestrant
An orally available, nonsteroidal selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD SAR439859 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.
| Synonym: | selective estrogen receptor degrader SAR439859 selective estrogen receptor downregulator SAR439859 SERD SAR439859 |
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| Code name: | SAR 439859 SAR-439859 |