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aminoglutethimide

A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production.
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Synonym:elipten
orimenten
US brand name:Cytadren
Foreign brand name:Aminoblastin
Mamomit
Orimeten
Orimetene
Rodazol
Code name:BA-16038
Chemical structure:2-(p-aminophenyl)-2-ethylglutarimide
3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione
3-ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine
alpha-(4-aminophenyl)-alpha-ethylglutarimide
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