amonafide dihydrochloride
The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.
| Synonym: | amonafide amonafide hydrochloride benzisoquinolinedione nafidimide |
|---|---|
| US brand name: | Quinamed |
| Abbreviation: | BIDA |
| Code name: | M-FA-142 |
| Chemical structure: | 1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl) |