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androgen receptor antagonist ONC1-0013B

An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist ONC1-13B specifically binds to AR, prevents AR activation, downregulates AR expression and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.
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Synonym:AR antagonist ONC1-0013B
Code name:ONC 10013B
ONC 113 B
ONC 113B
ONC-10013B
ONC1-0013B
ONC1-13B
ONC10013B
ONC113B
Chemical structure:(R)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxo-7-oxa-1,3-diazaspiro[4.4]nonan-1-yl)-2-fluoro-N-methylbenzamide
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