Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

anti-4-1BB/5T4 bispecific Aantibody ALG.APV-527

A human bispecific antibody composed of a single-chain variable fragment (scFv) domain targeting the immune co-stimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9) and a scFv domain targeting the tumor associated antigen (TAA) 5T4 (trophoblast glycoprotein; TPBG), that are linked through a mutated and silenced immunoglobulin G (IgG)-Fc domain, with potential immunomodulatory and antineoplastic activities. Upon administration of anti-4-1BB/5T4 bispecific antibody ALG.APV-527, the anti-5T4-specific scFv domain of ALG.APV-527 targets and binds to 5T4 expressed on tumor cells and the anti-4-1BB-specific scFv domain targets and binds to 4-1BB expressed on certain immune cells, such as T cells and natural killer cells (NK) cells within the tumor microenvironment (TME). This crosslinks T cells and tumor cells and allows for conditional 4-1BB activation, which stimulates the activation and proliferation of NKs and cytotoxic T lymphocytes (CTLs) in the TME leading to an anti-tumor immune response against the 5T4-expressing tumor cells. 5T4 is expressed on many different tumor cell types, including tumor-initiating cells, but expressed at low levels or not at all in normal tissue. ALG.APV-527 minimizes systemic immune activation and allows for tumor-specific responses that are localized to 5T4-positive tumors.
Synonym:4-1BB x 5T4 bispecific antibody ALG.APV-527
anti-4-1BB/anti-5T4 bispecific antibody ALG.APV-527
anti-5T4/4-1BB bispecific antibody ALG.APV-527
Code name:ALG.APV 527
ALG.APV-527
ALG.APV527
Search NCI's Drug Dictionary