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Anti-B7-H4/ TOP1i Antibody-drug Conjugate AZD8205

An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) linked to a topoisomerase-1 inhibitor (TOP1i; TOP-Ii), with potential antineoplastic activity. Upon administration, the anti-B7-H4 monoclonal antibody moiety of ADC AZD8205 targets and binds to B7-H4 expressed on tumor cells. Upon binding and internalization, the TOP1i moiety is released, binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes. This prevents DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA repair, and leads to cycle arrest and apoptosis specifically in tumor cells expressing B7-H4. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and tumor-associated macrophages. It negatively regulates T-cell immune responses.
Synonym:ADC AZD8205
anti-B7-H4/TOP1i ADC AZD8205
anti-B7-H4/topoisomerase I inhibitor ADC AZD8205
antibody-drug conjugate AZD8205
B7-H4 TOP1i ADC AZD8205
Code name:AZD 8205
AZD-8205
AZD8205
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