Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

anti-B7-H4/anti-4-1BB bispecific antibody ABL103

A T-cell engaging (TCE) bispecific antibody against both the tumor-associated antigen (TAA) B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-4-1BB bispecific antibody ABL103 targets and binds to both B7-H4 expressed on the surface of tumor cells and 4-1BB expressed on immune cells, including activated T lymphocytes, natural killer (NK) cells and NK-T cells. This crosslinks B7-H4-expressing tumor cells and 4-1BB-expressing T cells, NK cells and NK-T-cells, and activates 4-1BB signaling locally in the tumor microenvironment (TME) only when in the presence of B7-H4 expressing cells. This induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes a CTL-mediated anti-tumor immune response against tumor cells, induces NK-mediated tumor cell killing, and suppresses the immunosuppressive activity of regulatory T cells (Tregs). In addition, the blockage of B7-H4 by ABL103 directly prevents B7-H4-mediated inhibition of T cells. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and negatively regulates T-cell immune responses. B7-H4 expression in normal tissues is quite limited. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.
Synonym:4-1BB x B7-H4 bispecific antibody ABL103
ABL103, B7-H4 Grabody-T ABL103
anti-4-1BB/anti-B7-H4 bispecific antibody ABL103
anti-4-1BB/B7-H4 bispecific antibody ABL103
anti-B7-H4/4-1BB bispecific antibody ABL103
B7-H4x4-1BB bispecific antibody ABL103
TCE ABL103
Code name:ABL 103
ABL-103
ABL103
Search NCI's Drug Dictionary