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anti-CCR8 monoclonal antibody ABBV-514

An afucosylated monoclonal antibody directed against human C-C motif chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody ABBV-514 targets and binds to CCR8 on CCR8-positive, immunosuppressive tumor-infiltrating T-regulatory (TITR) cells in the tumor microenvironment (TME). This depletes CCR8-positive TITR cells via antibody-dependent cell-mediated cytotoxicity (ADCC), which may reverse the suppression of CD8+ effector T cells and reactivate antitumor immune responses. CCR8 is specifically expressed by TITR cells in multiple types of cancer and plays a key role in immunosuppression.
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Synonym:anti-C-C motif chemokine receptor 8 monoclonal antibody ABBV-514
anti-C-C-chemokine receptor 8 monoclonal antibody ABBV-514
Code name:ABBV 514
ABBV-514
ABBV514
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