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anti-CD123/CD3 BiTE antibody SAR440234

A bispecific T-cell engager (BiTE) antibody comprised of a humanized Fc-silenced immunoglobulin G1 (IgG1) backbone and two single-chain variable fragments (scFvs): one directed against the CD3 antigen expressed on T lymphocytes and another directed against the alpha-chain of the interleukin-3 receptor (IL-3RA; CD123), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion, anti-CD123/CD3 BiTE antibody SAR440234 binds to both CD3 expressed on T cells and CD123 expressed on tumor cells. This activates and redirects cytotoxic T lymphocytes (CTLs) to CD123-expressing tumor cells, leading to enhanced CTL-mediated elimination of CD123-expressing tumor cells. CD123 is overexpressed in a variety of hematological malignancies; its expression is low or absent in normal hematopoietic progenitors and stem cells.
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Synonym:bispecific T-cell engager antibody SAR440234
CD123xCD3 bispecific T-cell engager SAR440234
Code name:SAR 440234
SAR-440234
SAR440234
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