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anti-CD19/anti-CD3/anti-CD28 trispecific antibody CC312

A trispecific T-cell engager and antibody targeting the tumor-associated antigen (TAA) CD19, the T-cell surface antigen CD3, and the T-cell specific surface glycoprotein and co-stimulatory molecule CD28, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/anti-CD3/anti-CD28 trispecific antibody CC312 targets and binds to CD3 and CD28 on T cells and CD19 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.
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Synonym:anti-CD19/CD3/CD28 trispecific antibody CC312
CD19×CD3×CD28 trispecific antibody CC312
tri-specific T-cell engager CC312
TriTE CC312
Code name:CC 312
CC-312
CC312
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