anti-CD19/CD28 bispecific antibody RO7443904
A bispecific antibody directed against both the tumor-associated antigen (TAA) CD19 and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD28 bispecific antibody RO7443904 targets and binds to both CD28 expressed on T cells and CD19 expressed on tumor cells, which crosslinks the T cells to the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against the CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.
Synonym: | anti-CD19/anti-CD28 bispecific antibody RO7443904 anti-CD28/anti-CD19 bispecific antibody RO7443904 CD19 x CD28 bispecific antibody RO7443904 |
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Code name: | RG 6333 RG-6333 RG6333 RO 7443904 RO-7443904 RO7443904 |