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anti-CD45 BC8 monoclonal antibody-streptavidin conjugate

An immunoconjugate containing a monoclonal antibody directed against the CD45 antigen BC8, conjugated to streptavidin, a nonglycosylated homotetrameric protein that has four high affinity binding sites for biotin. Anti-CD45 BC8 antibody-streptavidin conjugate binds to CD45, a transmembrane protein tyrosine phosphatase that is expressed on the surface of normal and malignant hematopoietic cells. Upon administration of a biotin-based radioconjugate, the biotin moiety of the radioconjugate binds to the streptavidin moiety of anti-CD45 BC8 antibody-streptavidin conjugate and, upon cellular internalization, specifically delivers cytotoxic radiation to CD45-expressing tumor cells.
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Synonym:anti-CD45 BC8 antibody-streptavidin fusion protein
anti-CD45 monoclonal antibody BC8-streptavidin conjugate
BC8 scFv4SA fusion protein
Abbreviation:BC8-SA
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