Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

anti-CDH3/MMAE antibody-drug conjugate BC3195

An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the human tumor-associated antigen (TAA) cadherin-3 (CDH3; placental cadherin; P-cadherin), conjugated to the auristatin derivative and microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE) via a valine-citrulline (VC) peptide linker, with potential antineoplastic activity. Upon administration of anti-CDH3/MMAE ADC BC3195, the monoclonal antibody moiety targets and binds to CDH3 expressed on tumor cells. Upon internalization, proteolytic cleavage of linker, and the release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in CDH3-expressing tumor cells. In addition, BC3195 is able to induce a bystander effect on neighboring tumor cells. CDH3 is a member of the cadherin family; it is overexpressed in a variety of tumors and plays a role in cell adhesion, motility, invasion, and proliferation.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:anti-CDH3 ADC BC3195
anti-CDH3 antibody-drug conjugate BC3195
anti-CDH3/MMAE ADC BC3195
Code name:BC 3195
BC-3195
BC3195
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search