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anti-Claudin18.2 CAR T cells IBI345

A preparation of T lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 CAR T cells IBI345 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.

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Synonym:	anti-CLDN18.2 CAR T cells IBI345
Code name:	IBI 345 IBI-345 IBI345

anti-Claudin18.2 CAR T cells IBI345

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