anti-EGFR/c-Met/c-Met trispecific antibody BG-T187

A trispecific antibody targeting epidermal growth factor receptor (EGFR) and two different epitopes of hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/c-Met trispecific antibody BG-T187 simultaneously targets and binds to the extracellular domain of both EGFR and two different epitopes of c-Met expressed on tumor cells, thereby preventing receptor phosphorylation and activation of both EGFR- and c-Met-mediated signaling pathways. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.