Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

anti-ENTPD2 monoclonal antibody KAZ954

A monoclonal antibody directed against ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), with potential immunomodulating and antineoplastic activities. Upon administration, anti-ENTPD2 monoclonal antibody KAZ954 targets and binds to ENTPD2 expressed on a variety of tumor cells and inhibits its hydrolase activity, thereby preventing the conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP). This leads to an increased intra-tumoral ATP:ADP ratio, an increase in intra-tumoral monocytes, natural killer (NK) cells, peripheral CD8+ T cells, macrophages, and CD11b+ dendritic cells (DCs), and results in a systemic pro-inflammatory response in the tumor microenvironment (TME). In addition, KAZ954 induces antibody-dependent cellular cytotoxicity (ADCC) in ENTPD2-overexpressing tumor cells. ENTPD2 catalyzes the hydrolysis of ATP, reduces the cytotoxic antitumor immune response, enhances the proliferation and polarization of immunosuppressive cells, and increases neovascularization. It plays a key role in the creation of an immunosuppressive TME.
Synonym:anti-ectonucleoside triphosphate diphosphohydrolase 2 monoclonal antibody KAZ954
Code name:KAZ 954
KAZ-954
KAZ954
Search NCI's Drug Dictionary