anti-EpCAM monoclonal antibody AM-928

A humanized monoclonal antibody directed against the tumor-associated antigen (TAA) epithelial cell adhesion molecule (Ep-CAM; EpCAM; CD326), with potential antineoplastic activity. Upon administration, anti-EpCAM monoclonal antibody AM-928 targets and binds to EpCAM on EpCAM-expressing tumor cells. This inhibits EpCAM-mediated signaling and the proliferation of EpCAM-expressing tumor cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells.