Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

anti-FRalpha antibody-drug conjugate ZW191

An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated, via a maleimidocaproyl (MC) anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) protease-cleavable linker, to the camptothecin-based topoisomerase 1 inhibitor ZD06519, with potential antineoplastic activity. Upon administration of anti-FRalpha ADC ZW191, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon binding, cellular uptake and linker cleavage, ZD06519 is released. ZD06519 inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and generating DNA single- and double-strand breaks. This leads to cell cycle arrest and tumor cell apoptosis. In addition, ZD06519 is able to induce a bystander effect on neighboring cells in the tumor environment. This inhibits the proliferation of tumor cells. FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues.
Synonym:anti-FRa ADC ZW191
anti-FRa/ZD06519 ADC ZW191
anti-FRalpha ADC ZW191
Code name:ZW 191
ZW-191
ZW191
Search NCI's Drug Dictionary