anti-GPRC5D/anti-CD19 CAR T cells
A preparation of T lymphocytes engineered to express chimeric antigen receptor(s) (CARs) targeting the human tumor-associated antigens (TAAs) G-protein coupled receptor family C group 5 member D (GPRC5D) and CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPRC5D/anti-CD19 CAR T cells specifically and simultaneously target and bind to tumor cells expressing GPRC5D and/or CD19. This induces selective toxicity in tumor cells that express GPRC5D and/or CD19. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies.
Synonym: | anti-CD19/anti-GPRC5D CAR T cells anti-GPRC5D-CD19-CAR-T cells anti-GPRC5D/CD19 CAR T cells GPRC5D-CD19 CAR T cells |
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