Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

anti-HER2 antibody-drug conjugate BL-M07D1

An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-HER2 ADC BL-M07D1, the anti-HER2 monoclonal antibody moiety targets and binds to HER2 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills HER2-expressing tumor cells through an as of yet undisclosed mechanism. HER2, a receptor tyrosine kinase that is mutated or overexpressed in many tumor cell types, plays an important role in tumor cell proliferation and tumor vascularization.
Synonym:anti-HER2 ADC BL-M07D1
Code name:BL M07D1
BL-M07D1
BLM07D1
Search NCI's Drug Dictionary