anti-HLA-G/CD3 bispecific antibody RO7515629
A bispecific antibody targeting the tumor-associated antigen (TAA) histocompatibility antigen, class I, G (human leukocyte antigen G; HLA-G) and the CD3 antigen found on T lymphocytes, with potential immune checkpoint inhibiting, immunomodulating and antineoplastic activities. Upon administration, the anti-HLA-G/CD3 bispecific antibody RO7515629 targets and binds to both CD3 on cytotoxic T lymphocytes (CTLs) and HLA-G found on HLA-G-expressing tumor cells. This activates and redirects CTLs to HLA-G-expressing tumor cells, which results in the CTL-mediated cell death of HLA-G-expressing tumor cells. HLA-G, an immune checkpoint normally expressed at the maternal-fetal interface, is expressed across multiple tumor cell types and plays a key role in cancer immune evasion. It inhibits the immune responses by binding to its inhibitory receptors on a variety of immune cells, such as natural killer cells (NKs), T and B lymphocytes, and dendritic cells (DCs).
Synonym: | anti-HLA-G T-cell engager RO7515629 CD3-binding T-cell engager RO7515629 HLA-G TCB RO7515629 HLA-G-TCB RG6353 T-cell bispecific antibody RO7515629 TCB RO7515629 TCE RO7515629 |
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Code name: | RG 6353 RG-6353 RG6353 RO 7515629 RO-7515629 RO7515629 |