anti-human cytomegalovirus monoclonal antibody combination CSJ-148
A combination agent composed of two human monoclonal antibodies against the human cytomegalovirus (HCMV), LJP538 and LJP539, with potential immunomodulating activity. Upon administration of CSJ-148, both LJP538 and LJP539 bind to and inhibit the function of viral HCMV glycoproteins that are essential for HCMV infection; LJP538 targets and binds to glycoprotein B (gB) and LJP539 targets and inhibits the pentameric complex, consisting of glycoproteins gH, gL, UL128, UL130, and UL131. Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients.
| Synonym: | antiviral agent CSJ148 HCMV neutralizing human mAb combination CSJ-148 |
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| Code name: | CSJ 148 CSJ-148 CSJ148 LJP538 and LJP539 LJP538 plus LJP539 LJP538/LJP539 |