Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

anti-IGSF8 monoclonal antibody GV20-0251

A human, Fc-attenuated immunoglobulin G1 (IgG1) monoclonal antibody targeting the immune checkpoint immunoglobulin superfamily member 8 (IGSF8; PGRL; PG regulatory-like protein, KCT-4, CD81 partner 3; LIR-D1; KASP; KAI/CD82 associated protein; EWI-2; Glu-Trp-Ile EWI motif-containing protein 2), with potential immune checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-IGSF8 monoclonal antibody GV20-0251 targets and binds to IGSF8 expressed on various immune cells, thereby preventing the binding of IGSF8 to beta 1 integrins and various tetraspanins. This inhibits IGSF8-mediated signaling and abrogates the IGSF8-mediated inhibition on immune activation. This may stimulate a T-cell-mediated immune response against cancer cells. IGSF8, a transmembrane adhesion protein and member of the Ig super family (IgSF), is an immune inhibitory receptor that plays a key role in cancer cell motility and suppression of T-cell proliferation and activation. It is involved in tumor cell immune evasion and the inhibition of immune responses.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Code name:GV20 0251
GV20-0251
GV200251
XBH 25
XBH-25
XBH25
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search