anti-interleukin-13 receptor alpha 2 allogeneic CAR T cells YYB-103
A preparation of T lymphocytes genetically modified to express a chimeric antigen receptors (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-IL13Ra2 CAR T cells YYB-103 target and bind to IL13Ra2 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing IL13Ra2. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells.
Synonym: | anti-IL13Ra2 CAR T cells YYB-103 anti-IL13Ra2 CAR-T cells YYB-103 IL13Ra2-targeted CAR-T cells YYB-103 |
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Code name: | anti-IL13Ralpha2 CAR T cells YYB-103 YYB 103 YYB-103 YYB103 |