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anti-Lewis B/Lewis Y monoclonal antibody GNX102

A humanized monoclonal antibody directed against human tumor-associated carbohydrate antigens (TACAs) Lewis B (LeB) and Lewis Y (LeY), with potential antineoplastic activity. Upon administration, anti-LeB/LeY monoclonal antibody GNX102 binds to branched LeB and LeY glycans, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against LeB- and LeY-expressing tumor cells. LeB and LeY antigens, tetrasaccharides with low to moderate expression in monomeric form in normal adult tissues, is overexpressed in branched form in multiple forms of cancers.
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Synonym:anti-branched Lewis B/Lewis Y monoclonal antibody GNX102
anti-LeB/LeY monoclonal antibody GNX102
Code name:GNX 102
GNX-102
GNX102
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