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anti-MAGE-A4 T-cell receptor/anti-CD3 scFv fusion protein IMC-C103C

A T-cell re-directing bi-specific biologic composed of a modified form of human T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human melanoma-associated antigen A4 (MAGE-A4) and fused to an anti-CD3 single-chain variable fragment (scFv), with potential antineoplastic activity. Upon intravenous administration of IMC-C103C, the TCR moiety of this agent targets and binds to MAGE-A4 on tumor cells and the anti-CD3 scFv moiety binds to CD3- expressing T lymphocytes. This selectively cross-links tumor cells and T lymphocytes and results in a CTL-mediated death of MAGE-A4-expressing tumor cells. MAGE-A4 is overexpressed by a variety of cancer cell types.
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Synonym:ImmTAC IMC-C103C
ImmTAC Molecule IMC-C103C
immune mobilizing monoclonal TCR against cancer IMC-C103C
T-cell redirecting bi-specific biologic IMC-C103C
Code name:IMC C103C
IMC-C103C
IMCC103C
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