anti-MSLN/anti-CD3 bispecific antibody ZW171
A bispecific T-cell engager (TCE) and bispecific antibody directed against both the tumor-associated antigen (TAA) mesothelin (MSLN) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-MSLN/anti-CD3 bispecific antibody ZW171 bivalently binds to MSLN expressed on tumor cells and monovalently binds to CD3 expressed on cytotoxic T lymphocytes (CTLs). This activates and redirects CTLs to MSLN-expressing tumor cells, which results in the CTL-mediated death of MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.
| Synonym: | anti-mesothelin/anti-CD3 bispecific antibody ZW171 anti-MSLN/CD3 T-cell engaging bispecific antibody ZW171 MSLN x CD3 2 +1 bispecific antibody ZW171 MSLN-targeting T-cell engager ZW171 TCE ZW171 |
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| Code name: | ZW 171 ZW-171 ZW171 |