anti-OX40 agonist monoclonal antibody GEN1055
An agonistic, hexabody-based monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory and antineoplastic activities. Upon administration, anti-OX40 agonist monoclonal antibody GEN1055 selectively targets and binds to OX40, thereby forming a hexamer and inducing OX40 clustering. This activates OX40 and induces the proliferation of memory and effector T lymphocytes and inhibits the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). This enhances anti-tumor immune responses and prevents Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T lymphocytes and plays an essential role in T-cell activation and differentiation.
Synonym: | agonistic anti-OX40 monoclonal antibody GEN1055 |
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Code name: | BNT 315 BNT-315 BNT315 GEN 1055 GEN-1055 GEN1055 |