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anti-PSMA monoclonal antibody-MMAE conjugate

An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody directed against prostate-specific membrane antigen (PSMA), conjugated via a stable, enzyme-cleavable linker to monomethylauristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. The monoclonal antibody moiety of this conjugate selectively binds to PSMA, a protein which is abundantly expressed on the surface of metastatic and hormone-refractory prostate cancer cells. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis.
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Synonym:anti-PSMA monoclonal antibody-monomethylauristatin E conjugate
prostate-specific membrane antigen antibody-drug conjugate
Abbreviation:anti-PSMA-MMAE-ADC
Code name:PSMA ADC
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