Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

antigen-presenting cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV

A preparation of antigen presenting cells (APCs) specific for human papillomavirus (HPV) type 16 E6 and E7 proteins, with potential immunomodulating and antineoplastic activities. Autologous peripheral blood mononuclear cells (PBMCs) were ex vivo manipulated, using a technique involving membrane disruption to get the HPV16 E6 and E7 proteins into the cells; the resulting APCs present the antigens in a major histocompatibility type I (MHC-I) manner. Upon administration of the APCs-expressing HPV16 E6/E7 SQZ-PBMC-HPV, these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E6 and E7. HPV16 E6 and E7 play an important role in the development of certain types of cancer.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:APCs expressing HPV16 E6/E7 SQZ-PBMC-HPV
Code name:SQZ PBMC HPV
SQZ-PBMC-HPV
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search