NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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antineoplaston A10
A piperidinedione antineoplaston with potential antineoplastic activity. Antineoplaston A10 was originally isolated from human urine but is now synthetically derived. This agent intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis. Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Atengenal
Abbreviation:A10
Chemical structure:
  • 3-phenylacetylamino-2, 6-piperidinedione
  • benzeneacetamide, N-(2,6-dioxo-3-piperidinyl)-, (S)-