apolizumab
A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro.
| Synonym: | 1D10 anti-lymphoma antibody 1D1O anti-lymphoma antibody MAbHu1D10 monoclonal antibody 1D10 monoclonal antibody Hu1D10 |
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| US brand name: | Remitogen |
| Abbreviation: | MOAB 1D10 MoAb Hu1D10 |
| IND number: | 8308 9968 |
| NSC code: | 710066 |