asparaginase
An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.
Synonym: | ASP-1 asparaginase II asparaginase-E.coli colaspase L-ASP L-asparaginase L-asparagine amidohydrolase |
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US brand name: | Elspar L-Asnase |
Foreign brand name: | Kidrolase Laspar Leucogen Leunase Paronal Spectrila |
Abbreviation: | L-ASP Lcf-ASP |
Code name: | MK-965 Re-82-TAD-15 |