autologous AFP-specific T cell receptor T cells C-TCR055
A preparation of human autologous T lymphocytes transduced with a lentiviral vector encoding for a T-cell receptor (TCR) recognizing the human leukocyte antigen (HLA)-A*02:01 restricted human alpha-fetoprotein (AFP) 158-166 peptide (FMNKFIYEI), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the AFP specific TCR transduced T cells recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers while its expression is restricted in normal tissues.
Synonym: | autologous AFP-specific TCR-transduced T cells C-TCR055 |
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Code name: | C-TCR 055 C-TCR-055 C-TCR055 C-TCR055 |